Redifferentiation of iodine-refractory metastatic PTC with dabrafenib.
Ten patients with BRAF V600E-mutant iodine-refractory PTC received dabrafenib (150 mg twice daily) for 25 days prior to I-131 body scan (4 mCi). Patients whose scan showed new sites of uptake remained on dabrafenib for 17 more days, and then were treated with 150 mCi I-131. Six of ten demonstrated new uptake and were treated with I-131. Two had partial responses and 4 stable disease at three months, Tg decreased in 4.
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Rituximab in moderate-severe Graves Ophtalmopathy
Rituximab performed better than IV steroid in a randomized controlled study on 32 patients with GO published on line in JCEM. The better eye motility outcome, visual functioning of the quality of life assessment and the reduced number of surgical procedures in patients after RTX seem to suggest a disease modifying effect of the drug.
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People With T1D may Continue To Secrete Insulin Long After Diagnosis.
A Diabetes Care paper suggests that many people with T1DM continue to secrete small amounts of insulin long after diagnosis, particularly those who develop the condition in adolescence or adulthood. Residual insulin secretion was present in one of three people diagnosed with type 1 diabetes 3 years or earlier. In a separate study 80% of patients aged less than 30 years still had C-peptide levels 5 years after T1DM diagnosis.
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Some People May Be Extremely Obese Because Of Malfunctioning Form Of Leptin.
NEJM paper suggests some extremely obese people may be fat because their bodies produce a malfunctioning form of leptin. Investigators base this new theory on a 2-year-old boy of Turkish descent with an insatiable appetite who “was chronically obese for much of his short life.
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GLP-1 Receptor Agonists May Increase Dehydration Risk In Patients With T2D.
Individuals with type 2 diabetes have an elevated risk for dehydration due to high glucose levels, and research published in Journal of Neuroscience suggests that GLP-1 receptor agonists may increase this risk even more. GLP-1 is known to inhibit food intake, and an examination of the role of endogenous GLP-1 in rats revealed that the hormone exhibited a strong inhibitory effect on drinking behavior.
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Gigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation
X-linked acrogigantism is caused by an Xq26.3 genomic duplication and is characterized by early-onset gigantism resulting from an excess of growth hormone. Duplication of GPR101 probably causes X-LAG. A recurrent mutation in GPR101 was found in some adults with acromegaly and microduplication on chromosome Xq26.3 in samples from 13 patients with gigantism (4 members of two unrelated kindreds, and 9 sporadic).
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Testosterone Therapy May Not Increase Risk For Prostate Cancer.
Study in Journal of Urology reports prostate cancer risk not increased in hypogonadal men treated with testosterone therapy. Researchers also point to recommendations from the European Association of Urology and Endocrine Society guidelines that would allow testosterone therapy for those with localized treated prostate cancer and who are currently without any evidence of active disease and meet the diagnosis of hypogonadism.
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Metformin May Be Safer For Patients With Kidney Disease Than Believed.
An analysis in JAMA reports that metformin while usually not prescribed for people with kidney disease, may be safer than previously believed. Investigators, after reviewing published research found these patients were at no greater risk for lactic acidosis than people who were not taking the medication.
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T1D, T2D patients may have higher incidence and death from cancer
Medscape (12/16, McCall) reports that research published online in Diabetes Care suggests that individuals “with type 1 or type 2 diabetes have a higher incidence of cancer and death from cancer, with risks highest for certain specific tumors, compared with the general population.” Researchers found that “the highest excess risks were observed for cancers of the pancreas, liver, endometrium, kidney, thyroid, and gallbladder and for chronic myeloid leukemia.”
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Maternal Vitamin D Deficiency and Long-Term Outcomes In Offspring.
Maternal vitamin D deficiency is associated with multisystem long-term health outcomes in offspring, according to a summative review of five published substudies published in Pediatrics. The longitudinal, prospective study of 901 mother and offspring indicate that children born to mothers with serum vitamin D less than 50 nmol/L at 18 weeks gestation were at increased risk for impaired lung development at 6 years, neurocognitive problems at 10 years, eating disorders during adolescence, and lower peak bone mass at 20 years.
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Look Deeper Into Possible Link Between SGLT2 Inhibitors, Bone Fractures.
Look deeper into the potential relationship between SGLT2 inhibitors and bone fractures as it is biologically plausible that this class of drug could have an impact on fracture, researchers urged in a comment in The Lancet Diabetes & Endocrinology
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