Department of Biological Regulation Weizmann Institute of Scienceמנהל: |
In my laboratory
we are studying all of the above cascades, although our main studies
in the last years focused on the extracellular signal-regulated kinase
(ERK) cascade. Since ERK activation occurs in response to diverse stimuli,
and it can regulate large number of distinct cellular processes, one
of the key questions in the field is the determination of the signaling
specificity of the ERK cascade. In other words, what are the mechanisms
that allow similar ERK activations to result in such a diverse array
of downstream effects? In the past years we concentrated on several
such mechanisms, including: (i) Compartmentalization and subcellular
localization that may direct ERK signals to distinct targets. (ii)
The production of alternatively spliced forms of the ERK with distinct
substrate specificities. (iii) Crosstalk with other signaling cascades
that may modify the signaling outcome. (iv) Regulation of the ERK cascade
by phosphatases, which are the tool that governs the duration of the
signal and thereby modulate the repertoire of ERK’s targets. Few of
our recent findings are: |
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